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The focus of the Zhang lab is to dissect RNA regulatory networks in the nervous system as a way to understand the mammalian complexity manifested in evolutionary-developmental (evo-devo) processes and in several neuronal disorders. We work on a range of problems towards the goal, including mechanistic understanding of the specificity of protein-RNA interactions, organizational principles of RNA regulatory networks, and functional implication of RNA regulation in neural development and in certain pathologic contexts (such as autism and neurodegenerative disorders).  The Zhang lab has a mixed dry and wet setup. We take advantage of different model systems, including mouse models and in vitro neural differentiation of embryonic stem cells, and a combination of high-throughput data-driven and hypothesis-driven approaches.
 
The focus of the Zhang lab is to dissect RNA regulatory networks in the nervous system as a way to understand the mammalian complexity manifested in evolutionary-developmental (evo-devo) processes and in several neuronal disorders. We work on a range of problems towards the goal, including mechanistic understanding of the specificity of protein-RNA interactions, organizational principles of RNA regulatory networks, and functional implication of RNA regulation in neural development and in certain pathologic contexts (such as autism and neurodegenerative disorders).  The Zhang lab has a mixed dry and wet setup. We take advantage of different model systems, including mouse models and in vitro neural differentiation of embryonic stem cells, and a combination of high-throughput data-driven and hypothesis-driven approaches.
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Cold Spring Harbor Asia (CSHA) Conference on '''[http://www.csh-asia.org/2020meetings/COMP.html Computational Biology of the Genome]'''. June 29 - July 3, 2020. Suzhou, China.  Abstract deadline: April 17, 2020. (postponed due to nCOVID. stay tuned for update).
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'''Lab News''' ([[Lab news|all lab news]])
 
'''Lab News''' ([[Lab news|all lab news]])
* 01/24/2019. "The splicing code goes deep" - A preview on splicing is published in [http://www.sciencedirect.com/science/article/pii/S0092867419300467?dgcid=author Cell].
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* 02/01/2021. Our recent work on neuronal cell type-specific regulation is now on [http://www.biorxiv.org/content/10.1101/2021.01.27.428525v1 bioRiv].
* 10/08/2018. Congratulate Huijuan Feng and Suying Bao for winning the poster award in Systems Biology departmental retreat!
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* 07/15/2020. We are one of the winners of the Columbia Precision Medicine Pilot Grants.  With this seed fund, we will work on a high-throughput screening approach of splicing-regulatory elements. [http://cancer.columbia.edu/pilot-grants-advance-innovative-precision-medicine-research news release].
* 09/25/2018. A [http://link.springer.com/article/10.1007/s40484-018-0152-7 special issue on RNA processing and regulation] co-edited by Chaolin Zhang is out in Quantitative Biology.  
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* 06/23/2019. Our mCross paper is now published in [http://www.sciencedirect.com/science/article/pii/S1097276519300929?dgcid=author Molecular Cell]. see [http://systemsbiology.columbia.edu/news/novel-computational-tool-models-rna-binding-specificity-provides-better-understanding-of-gene news release].
  
  

Latest revision as of 09:18, 1 February 2021

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Introduction of the Zhang Laboratory

We are part of the Department of Systems Biology, the Department of Biochemistry and Molecular Biophysics, and the Motor Neuron Center at Columbia University Medical Center.

We are fascinated by the complexity of the mammalian nervous system and its underlying molecular mechanisms. While mammals have a similar number of genes compared to phenotypically simpler organisms (such as worms), one apparent feature of mammalian genes is their more complicated gene structures, providing an opportunity for sophisticated regulation at the RNA level.

The focus of the Zhang lab is to dissect RNA regulatory networks in the nervous system as a way to understand the mammalian complexity manifested in evolutionary-developmental (evo-devo) processes and in several neuronal disorders. We work on a range of problems towards the goal, including mechanistic understanding of the specificity of protein-RNA interactions, organizational principles of RNA regulatory networks, and functional implication of RNA regulation in neural development and in certain pathologic contexts (such as autism and neurodegenerative disorders). The Zhang lab has a mixed dry and wet setup. We take advantage of different model systems, including mouse models and in vitro neural differentiation of embryonic stem cells, and a combination of high-throughput data-driven and hypothesis-driven approaches.

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Cold Spring Harbor Asia (CSHA) Conference on Computational Biology of the Genome. June 29 - July 3, 2020. Suzhou, China. Abstract deadline: April 17, 2020. (postponed due to nCOVID. stay tuned for update).


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Lab News (all lab news)

  • 02/01/2021. Our recent work on neuronal cell type-specific regulation is now on bioRiv.
  • 07/15/2020. We are one of the winners of the Columbia Precision Medicine Pilot Grants. With this seed fund, we will work on a high-throughput screening approach of splicing-regulatory elements. news release.
  • 06/23/2019. Our mCross paper is now published in Molecular Cell. see news release.