Difference between revisions of "Main Page"

From Zhang Laboratory

Jump to: navigation, search
 
(22 intermediate revisions by the same user not shown)
Line 63: Line 63:
  
 
             <div>
 
             <div>
                 <a u=image href="/index.php/Research" rel="nofollow"><img u="image" src="/data/images/slideshow/deconstruct_splice_code.png" width="600" height="300" /></a>
+
                 <a u=image href="/index.php/Research" title="Our long term goal: better mechanistic understanding of RNA splicing regulation and function."  rel="nofollow"><img u="image" src="/data/images/slideshow/deconstruct_splice_code.png" width="600" height="300" /></a>
 
             </div>
 
             </div>
  
 
           <div>
 
           <div>
                 <a u=image href="https://authors.elsevier.com/a/1ZFv83vVUP9pz1" rel="nofollow"><img u="image" src="/data/images/slideshow/mcross.png" width="600" height="300" /></a>
+
                <a u=image href="https://www.pnas.org/content/118/10/e2013056118/tab-article-info" title="Clustering of neuronal subtypes based on splicing profiles (PNAS, 2021)." rel="nofollow"><img u="image" src="/data/images/slideshow/neuronal_subtype_splicing.png" width="600" height="300" /></a>
 +
            </div>
 +
 
 +
          <div>
 +
                 <a u=image href="https://authors.elsevier.com/a/1ZFv83vVUP9pz1" title="mCross: precise registration of protein-RNA crosslink sites to define RBP binding specificity using CLIP data (Mol. Cell, 2019)." rel="nofollow"><img u="image" src="/data/images/slideshow/mcross.png" width="600" height="300" /></a>
 
             </div>
 
             </div>
  
  
 
             <div>
 
             <div>
                 <a u=image href="https://authors.elsevier.com/a/1XPn83vVUP60qL" rel="nofollow"><img u="image" src="/data/images/slideshow/lin28.png" width="600" height="300" /></a>
+
                 <a u=image href="https://authors.elsevier.com/a/1XPn83vVUP60qL" title="A subclass of let-7 microRNA partially escape from LIN28 repression (Mol. Cell, 2018)." rel="nofollow"><img u="image" src="/data/images/slideshow/lin28.png" width="600" height="300" /></a>
 
             </div>
 
             </div>
  
 
             <div>
 
             <div>
                 <a u=image href="https://www.nature.com/articles/s41467-018-04559-0" rel="nofollow"><img u="image" src="/data/images/slideshow/devas.png" width="600" height="300" /></a>
+
                 <a u=image href="https://www.nature.com/articles/s41467-018-04559-0" title="Precise timing of alternative splicing switches during neuronal development (Nat. Commun., 2018)" rel="nofollow"><img u="image" src="/data/images/slideshow/devas.png" width="600" height="300" /></a>
 
             </div>
 
             </div>
  
  
 
             <div>
 
             <div>
                 <a u=image href="http://www.cell.com/neuron/fulltext/S0896-6273(18)30023-0" rel="nofollow"><img u="image" src="/data/images/slideshow/ais.jpg" width="600" height="300" /></a>
+
                 <a u=image href="http://www.cell.com/neuron/fulltext/S0896-6273(18)30023-0" title="Rbfox regulates axon initial segment and neuronal excitability (Neuron, 2018)." rel="nofollow"><img u="image" src="/data/images/slideshow/ais.jpg" width="600" height="300" /></a>
 
             </div>
 
             </div>
  
 
             <div>
 
             <div>
                 <a u=image href="http://www.cell.com/neuron/fulltext/S0896-6273(18)30023-0" rel="nofollow"><img u="image" src="/data/images/slideshow/RbfoxMN.png" width="600" height="300" /></a>
+
                 <a u=image href="http://www.cell.com/neuron/fulltext/S0896-6273(18)30023-0" title="Rbfox regulates axon initial segment and neuronal excitability (Neuron, 2018)." rel="nofollow"><img u="image" src="/data/images/slideshow/RbfoxMN.png" width="600" height="300" /></a>
 
             </div>
 
             </div>
  
 
             <div>
 
             <div>
                 <a u=image href="http://onlinelibrary.wiley.com/doi/10.1002/humu.23147/abstract" rel="nofollow"><img u="image" src="/data/images/slideshow/DAMAGES.png" width="600" height="300" /></a>
+
                 <a u=image href="http://onlinelibrary.wiley.com/doi/10.1002/humu.23147/abstract" title="A neuronal-cell type-specific gene expression signature predicts autism risk genes (Hum. Mut. 2017)." rel="nofollow"><img u="image" src="/data/images/slideshow/DAMAGES.png" width="600" height="300" /></a>
 
             </div>
 
             </div>
  
 
             <div>
 
             <div>
                 <a u=image href="/index.php/Research" rel="nofollow"><img u="image" src="/data/images/slideshow/dual_splice_site.png" width="600" height="300" /></a>
+
                 <a u=image href="/index.php/Research" title="Genes have 5' splice sites and 3' splice sites, but some splice sites have dual roles"  rel="nofollow"><img u="image" src="/data/images/slideshow/dual_splice_site.png" width="600" height="300" /></a>
 
             </div>
 
             </div>
  
 
             <div>
 
             <div>
                 <a u=image href="/index.php/Research" rel="nofollow"><img u="image" src="/data/images/slideshow/crosslink.png" width="600" height="300" /></a>
+
                 <a u=image href="/index.php/Research" title="UV-crosslinking induced protein-RNA adducts provide a signature to determine protein-RNA interactions at single nucleotide resolution" rel="nofollow"><img u="image" src="/data/images/slideshow/crosslink.png" width="600" height="300" /></a>
 
             </div>
 
             </div>
  
 
             <div>
 
             <div>
                 <a u=image href="/index.php/Research" rel="nofollow"><img u="image" src="/data/images/slideshow/bnet.png" width="600" height="300" /></a>
+
                 <a u=image href="/index.php/Research" title="An integrative modeling approach to construct splicing regulatory networks" rel="nofollow"><img u="image" src="/data/images/slideshow/bnet.png" width="600" height="300" /></a>
 
             </div>
 
             </div>
 
              
 
              
 
             <div>
 
             <div>
                 <a u=image href="/index.php/Research" rel="nofollow"><img u="image" src="/data/images/slideshow/brain_dev.png" width="600" height="300" /></a>
+
                 <a u=image href="/index.php/Research" title="We aim to understand the contribution to alternative splicing to transcriptome diversity in brain development" rel="nofollow"><img u="image" src="/data/images/slideshow/brain_dev.png" width="600" height="300" /></a>
 
             </div>
 
             </div>
  
 
             <div>
 
             <div>
                 <a u=image href="/index.php/Research" rel="nofollow"><img u="image" src="/data/images/slideshow/eb.png" width="600" height="300" /></a>
+
                 <a u=image href="/index.php/Research" title="ESC-derived motor neuronsprovide an ideal system to model neural development and maturation in vitro" rel="nofollow"><img u="image" src="/data/images/slideshow/eb.png" width="600" height="300" /></a>
 
             </div>
 
             </div>
  
Line 137: Line 141:
 
<center>---</center>
 
<center>---</center>
  
Cold Spring Harbor Asia (CSHA) Conference on [http://www.csh-asia.org/2020meetings/COMP.html Computational Biology of the Genome]. June 27 - July 3, 2020. Suzhou, China.  Abstract deadline: April 17. 2020.
+
 
 +
Cold Spring Harbor Asia (CSHA) Conference on '''[http://www.csh-asia.org/2020meetings/COMP.html Computational Biology of the Genome]'''. June 29 - July 3, 2020. Suzhou, China.  Abstract deadline: April 17, 2020. (postponed due to nCOVID. stay tuned for update).
  
  
Line 144: Line 149:
  
 
'''Lab News''' ([[Lab news|all lab news]])
 
'''Lab News''' ([[Lab news|all lab news]])
* 06/23/2019. Our mCross paper is now published in [http://www.sciencedirect.com/science/article/pii/S1097276519300929?dgcid=author Molecular Cell].  see [http://systemsbiology.columbia.edu/news/novel-computational-tool-models-rna-binding-specificity-provides-better-understanding-of-gene news release].
+
* 04/13/2021. Congrats Melissa McKenzie, postdoc in the lab, on winning the prestigious NIH K99 award.
* 04/09/2019. Congrats Yocelyn Recinos, graduate student in the lab, for winning the NSF Graduate Research Fellowship.
+
* 03/10/2021. Our recent work on neuronal cell type-specific regulation is now officially on [http://www.pnas.org/content/118/10/e2013056118 PNAS].
* 04/02/2019. Chaolin is officially approved for tenure at Columbia.  Congratulate him on [http://twitter.com/chaolinzhang/status/1111669605620170753 twitter]!
+
* 02/01/2021. Our recent work on neuronal cell type-specific regulation is now on [http://www.biorxiv.org/content/10.1101/2021.01.27.428525v1 bioRiv].
 +
 
  
  

Latest revision as of 21:20, 14 April 2021

Facebook.png Twitter.jpg

Javascript Slideshow


Introduction of the Zhang Laboratory

We are part of the Department of Systems Biology, the Department of Biochemistry and Molecular Biophysics, and the Motor Neuron Center at Columbia University Medical Center.

We are fascinated by the complexity of the mammalian nervous system and its underlying molecular mechanisms. While mammals have a similar number of genes compared to phenotypically simpler organisms (such as worms), one apparent feature of mammalian genes is their more complicated gene structures, providing an opportunity for sophisticated regulation at the RNA level.

The focus of the Zhang lab is to dissect RNA regulatory networks in the nervous system as a way to understand the mammalian complexity manifested in evolutionary-developmental (evo-devo) processes and in several neuronal disorders. We work on a range of problems towards the goal, including mechanistic understanding of the specificity of protein-RNA interactions, organizational principles of RNA regulatory networks, and functional implication of RNA regulation in neural development and in certain pathologic contexts (such as autism and neurodegenerative disorders). The Zhang lab has a mixed dry and wet setup. We take advantage of different model systems, including mouse models and in vitro neural differentiation of embryonic stem cells, and a combination of high-throughput data-driven and hypothesis-driven approaches.

---


Cold Spring Harbor Asia (CSHA) Conference on Computational Biology of the Genome. June 29 - July 3, 2020. Suzhou, China. Abstract deadline: April 17, 2020. (postponed due to nCOVID. stay tuned for update).


---


Lab News (all lab news)

  • 04/13/2021. Congrats Melissa McKenzie, postdoc in the lab, on winning the prestigious NIH K99 award.
  • 03/10/2021. Our recent work on neuronal cell type-specific regulation is now officially on PNAS.
  • 02/01/2021. Our recent work on neuronal cell type-specific regulation is now on bioRiv.